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Assay Detail

CHEMBL973268

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Binding
Inhibition of maize histone deacetylase 1B
ChEMBL ↗
55
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Zea mays
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histone deacetylase HD1B (CHEMBL3541) ↗
Type SINGLE PROTEIN
Organism Zea mays

Publication

Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies.
Ragno R, Simeoni S, Rotili D, Caroli A, Botta G, Brosch G, Massa S, Mai A.
Eur J Med Chem (2008) 43 : 621 -632
PubMed 17698257 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 55 5.49 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 9.40
CHEMBL98 VORINOSTAT 4.0 1 7.52
CHEMBL192870 — — 1 6.77
CHEMBL365535 — — 1 6.75
CHEMBL145685 — — 1 6.58
CHEMBL192098 — — 1 6.48
CHEMBL145116 — — 1 6.41
CHEMBL364970 — — 1 6.32
CHEMBL516957 — — 2 6.29
CHEMBL516805 — — 2 6.29
CHEMBL365372 — — 1 6.24
CHEMBL192199 — — 1 6.22
CHEMBL461493 — — 2 6.21
CHEMBL191623 — — 1 6.10
CHEMBL460876 — — 2 6.10
CHEMBL461492 — — 2 6.09
CHEMBL460672 — — 2 6.09
CHEMBL142441 — — 1 5.80
CHEMBL370253 — — 1 5.75
CHEMBL415533 — — 1 5.60
CHEMBL371806 — — 1 5.47
CHEMBL191852 — — 1 5.35
CHEMBL145099 — — 1 5.32
CHEMBL460671 — — 1 5.19
CHEMBL461079 — — 2 4.92
CHEMBL461494 — — 2 4.92
CHEMBL461078 — — 2 4.87
CHEMBL512566 — — 2 4.76
CHEMBL510415 — — 1 4.71
CHEMBL454194 — — 2 4.67

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 0.4 nM 9.40
CHEMBL98 VORINOSTAT IC50 = 30.0 nM 7.52
CHEMBL192870 — IC50 = 170.0 nM 6.77
CHEMBL365535 — IC50 = 180.0 nM 6.75
CHEMBL145685 — IC50 = 260.0 nM 6.58
CHEMBL192098 — IC50 = 330.0 nM 6.48
CHEMBL145116 — IC50 = 390.0 nM 6.41
CHEMBL364970 — IC50 = 480.0 nM 6.32
CHEMBL516957 — IC50 = 510.0 nM 6.29
CHEMBL516805 — IC50 = 510.5 nM 6.29
CHEMBL365372 — IC50 = 570.0 nM 6.24
CHEMBL192199 — IC50 = 600.0 nM 6.22
CHEMBL461493 — IC50 = 620.87 nM 6.21
CHEMBL516805 — IC50 = 621.0 nM 6.21
CHEMBL191623 — IC50 = 800.0 nM 6.10
CHEMBL460876 — IC50 = 799.83 nM 6.10
CHEMBL461492 — IC50 = 807.0 nM 6.09
CHEMBL460672 — IC50 = 807.24 nM 6.09
CHEMBL516957 — IC50 = 1399.59 nM 5.85
CHEMBL461493 — IC50 = 1400.0 nM 5.85
CHEMBL142441 — IC50 = 1600.0 nM 5.80
CHEMBL370253 — IC50 = 1800.0 nM 5.75
CHEMBL415533 — IC50 = 2500.0 nM 5.60
CHEMBL371806 — IC50 = 3400.0 nM 5.47
CHEMBL191852 — IC50 = 4500.0 nM 5.35
CHEMBL145099 — IC50 = 4800.0 nM 5.32
CHEMBL460671 — IC50 = 6400.0 nM 5.19
CHEMBL461079 — IC50 = 11994.99 nM 4.92
CHEMBL461494 — IC50 = 12000.0 nM 4.92
CHEMBL461078 — IC50 = 13489.63 nM 4.87
CHEMBL461078 — IC50 = 13500.0 nM 4.87
CHEMBL460876 — IC50 = 16600.0 nM 4.78
CHEMBL461079 — IC50 = 17000.0 nM 4.77
CHEMBL461492 — IC50 = 16982.44 nM 4.77
CHEMBL512566 — IC50 = 17179.08 nM 4.76
CHEMBL512566 — IC50 = 17200.0 nM 4.76
CHEMBL510415 — IC50 = 19700.0 nM 4.71
CHEMBL454194 — IC50 = 21300.0 nM 4.67
CHEMBL454194 — IC50 = 21281.39 nM 4.67
CHEMBL453044 — IC50 = 22600.0 nM 4.65
CHEMBL511523 — IC50 = 23500.0 nM 4.63
CHEMBL511523 — IC50 = 23496.33 nM 4.63
CHEMBL192960 — IC50 = 24300.0 nM 4.61
CHEMBL192533 — IC50 = 24900.0 nM 4.60
CHEMBL454599 — IC50 = 25800.0 nM 4.59
CHEMBL145531 — IC50 = 29400.0 nM 4.53
CHEMBL189381 — IC50 = 31800.0 nM 4.50
CHEMBL145028 — IC50 = 31400.0 nM 4.50
CHEMBL191089 — IC50 = 38800.0 nM 4.41
CHEMBL461494 — IC50 = 59020.11 nM 4.23