Assay Detail
Functional
CHEMBL973272
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Antiprotozoal activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1
31
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.99 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.92 |
| CHEMBL459423 | — | — | 2 | 6.70 |
| CHEMBL459437 | — | — | 2 | 6.33 |
| CHEMBL459424 | — | — | 2 | 6.32 |
| CHEMBL518623 | — | — | 2 | 6.31 |
| CHEMBL518622 | — | — | 2 | 6.30 |
| CHEMBL459436 | — | — | 2 | 6.26 |
| CHEMBL516624 | — | — | 2 | 6.21 |
| CHEMBL516462 | — | — | 2 | 6.18 |
| CHEMBL518333 | — | — | 2 | 6.10 |
| CHEMBL460449 | — | — | 2 | 6.10 |
| CHEMBL375980 | — | — | 2 | 6.08 |
| CHEMBL518167 | — | — | 2 | 6.07 |
| CHEMBL518332 | — | — | 2 | 5.93 |
| CHEMBL219419 | — | — | 2 | 5.91 |
| CHEMBL374245 | — | — | 2 | 4.88 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL459423 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL459437 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL459424 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL518623 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL518622 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL459436 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL516624 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL516624 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL516462 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL459437 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL516462 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL518333 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL460449 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL375980 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL518167 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL459436 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL518333 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL518623 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL518332 | — | IC50 | = | 1180.0 | nM | 5.93 |
| CHEMBL219419 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL518622 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL459423 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL219419 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL518332 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL375980 | — | IC50 | = | 2770.0 | nM | 5.56 |
| CHEMBL460449 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL518167 | — | IC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL374245 | — | IC50 | = | 13130.0 | nM | 4.88 |
| CHEMBL374245 | — | IC50 | > | 15550.0 | nM | - |
| CHEMBL459424 | — | IC50 | - | — | - |