Assay Detail
Binding
CHEMBL973384
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Inhibition of human erythrocytes mu-calpain by spectrofluorimeter
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of calpain inhibitory 6-pyridone 2-carboxamide derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.88 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 7.16 |
| CHEMBL492083 | — | — | 1 | 5.55 |
| CHEMBL492081 | — | — | 1 | 5.21 |
| CHEMBL491919 | — | — | 1 | 5.21 |
| CHEMBL491918 | — | — | 1 | 5.13 |
| CHEMBL491749 | — | — | 1 | 4.66 |
| CHEMBL492082 | — | — | 1 | 4.47 |
| CHEMBL522312 | — | — | 1 | 4.45 |
| CHEMBL489722 | — | — | 1 | 4.40 |
| CHEMBL490564 | — | — | 1 | 4.19 |
| CHEMBL524152 | — | — | 1 | 4.07 |
| CHEMBL489721 | — | — | 1 | 4.04 |
| CHEMBL489723 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL492083 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL492081 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL491919 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL491918 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL491749 | — | IC50 | = | 22130.0 | nM | 4.66 |
| CHEMBL492082 | — | IC50 | = | 34010.0 | nM | 4.47 |
| CHEMBL522312 | — | IC50 | = | 35260.0 | nM | 4.45 |
| CHEMBL489722 | — | IC50 | = | 40170.0 | nM | 4.40 |
| CHEMBL490564 | — | IC50 | = | 64610.0 | nM | 4.19 |
| CHEMBL524152 | — | IC50 | = | 84750.0 | nM | 4.07 |
| CHEMBL489721 | — | IC50 | = | 91420.0 | nM | 4.04 |
| CHEMBL489723 | — | IC50 | > | 100000.0 | nM | - |