Assay Detail
Binding
CHEMBL973408
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Binding affinity to OX2 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Conformational analysis of N,N-disubstituted-1,4-diazepane orexin receptor antagonists and implications for receptor binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.52 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL469146 | — | — | 1 | 9.22 |
| CHEMBL469147 | — | — | 1 | 8.70 |
| CHEMBL512778 | — | — | 1 | 7.38 |
| CHEMBL466260 | — | — | 1 | 6.92 |
| CHEMBL466259 | — | — | 1 | 6.62 |
| CHEMBL511604 | — | — | 1 | 6.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL469146 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL469147 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL512778 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL466260 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL466259 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL511604 | — | Ki | = | 550.0 | nM | 6.26 |