Assay Detail
Binding
CHEMBL973551
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Displacement of [3H]clonidine from Imidazoline receptor 1 in Sprague-Dawley rat kidney membrane
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Kidney |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.16 | 5.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL508960 | — | — | 1 | 5.54 |
| CHEMBL506350 | — | — | 1 | 5.45 |
| CHEMBL525531 | — | — | 1 | 5.40 |
| CHEMBL506016 | — | — | 1 | 5.37 |
| CHEMBL498476 | — | — | 1 | 5.16 |
| CHEMBL498261 | — | — | 1 | 5.14 |
| CHEMBL450405 | — | — | 1 | 5.13 |
| CHEMBL448918 | — | — | 1 | 4.62 |
| CHEMBL497458 | — | — | 1 | 4.59 |
| CHEMBL452401 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL508960 | — | IC50 | = | 2877.0 | nM | 5.54 |
| CHEMBL506350 | — | IC50 | = | 3569.0 | nM | 5.45 |
| CHEMBL525531 | — | IC50 | = | 3998.0 | nM | 5.40 |
| CHEMBL506016 | — | IC50 | = | 4255.0 | nM | 5.37 |
| CHEMBL498476 | — | IC50 | = | 6891.0 | nM | 5.16 |
| CHEMBL498261 | — | IC50 | = | 7301.0 | nM | 5.14 |
| CHEMBL450405 | — | IC50 | = | 7360.0 | nM | 5.13 |
| CHEMBL448918 | — | IC50 | = | 23890.0 | nM | 4.62 |
| CHEMBL497458 | — | IC50 | = | 25812.0 | nM | 4.59 |
| CHEMBL452401 | — | IC50 | = | 211600.0 | nM | - |