Assay Detail
Binding
CHEMBL973552
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Displacement of [3H]2-BFI from Imidazoline receptor 2 in Sprague-Dawley rat whole brain membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.76 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL497458 | — | — | 1 | 8.94 |
| CHEMBL506016 | — | — | 1 | 8.82 |
| CHEMBL450405 | — | — | 1 | 8.78 |
| CHEMBL14210 | PHENYZOLINE | — | 1 | 8.60 |
| CHEMBL506350 | — | — | 1 | 8.32 |
| CHEMBL508960 | — | — | 1 | 8.11 |
| CHEMBL498476 | — | — | 1 | 8.05 |
| CHEMBL498261 | — | — | 1 | 7.13 |
| CHEMBL501690 | — | — | 1 | 6.80 |
| CHEMBL525531 | — | — | 1 | 6.60 |
| CHEMBL448918 | — | — | 1 | 6.59 |
| CHEMBL452401 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL497458 | — | Ki | = | 1.16 | nM | 8.94 |
| CHEMBL506016 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL450405 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL14210 | PHENYZOLINE | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL506350 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL508960 | — | Ki | = | 7.72 | nM | 8.11 |
| CHEMBL498476 | — | Ki | = | 8.89 | nM | 8.05 |
| CHEMBL498261 | — | Ki | = | 73.5 | nM | 7.13 |
| CHEMBL501690 | — | Ki | = | 158.5 | nM | 6.80 |
| CHEMBL525531 | — | Ki | = | 251.9 | nM | 6.60 |
| CHEMBL448918 | — | Ki | = | 254.3 | nM | 6.59 |
| CHEMBL452401 | — | Ki | = | 413.6 | nM | 6.38 |