Assay Detail
Binding
CHEMBL973553
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]RX821002 from Adrenergic alpha2 receptor in Sprague-Dawley rat whole brain membrane
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel ligands rationally designed for characterizing I2-imidazoline binding sites nature and functions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.82 | 6.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498476 | — | — | 1 | 6.53 |
| CHEMBL506016 | — | — | 1 | 6.53 |
| CHEMBL497458 | — | — | 1 | 6.42 |
| CHEMBL450405 | — | — | 1 | 6.25 |
| CHEMBL508960 | — | — | 1 | 6.09 |
| CHEMBL498261 | — | — | 1 | 6.03 |
| CHEMBL525531 | — | — | 1 | 5.95 |
| CHEMBL14210 | PHENYZOLINE | — | 1 | 5.70 |
| CHEMBL506350 | — | — | 1 | 5.53 |
| CHEMBL448918 | — | — | 1 | 5.45 |
| CHEMBL501690 | — | — | 1 | 5.15 |
| CHEMBL452401 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498476 | — | Ki | = | 292.7 | nM | 6.53 |
| CHEMBL506016 | — | Ki | = | 295.4 | nM | 6.53 |
| CHEMBL497458 | — | Ki | = | 381.0 | nM | 6.42 |
| CHEMBL450405 | — | Ki | = | 557.7 | nM | 6.25 |
| CHEMBL508960 | — | Ki | = | 819.9 | nM | 6.09 |
| CHEMBL498261 | — | Ki | = | 925.9 | nM | 6.03 |
| CHEMBL525531 | — | Ki | = | 1117.9 | nM | 5.95 |
| CHEMBL14210 | PHENYZOLINE | Ki | = | 1985.0 | nM | 5.70 |
| CHEMBL506350 | — | Ki | = | 2962.0 | nM | 5.53 |
| CHEMBL448918 | — | Ki | = | 3540.0 | nM | 5.45 |
| CHEMBL501690 | — | Ki | = | 7132.0 | nM | 5.15 |
| CHEMBL452401 | — | Ki | = | 64773.0 | nM | 4.19 |