Assay Detail
Binding
CHEMBL973573
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Inhibition of TrxR preincuabatd for 2 mins
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of curcumin analogues as potential thioredoxin reductase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.19 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504623 | — | — | 1 | 6.52 |
| CHEMBL487882 | — | — | 1 | 6.30 |
| CHEMBL488901 | — | — | 1 | 6.10 |
| CHEMBL210395 | — | — | 1 | 6.00 |
| CHEMBL488900 | — | — | 1 | 5.89 |
| CHEMBL454667 | — | — | 1 | 5.80 |
| CHEMBL487035 | — | — | 1 | 5.70 |
| CHEMBL486870 | — | — | 1 | 5.29 |
| CHEMBL486851 | — | — | 1 | 4.86 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | — | 1 | 4.70 |
| CHEMBL487003 | — | — | 1 | 4.70 |
| CHEMBL487881 | — | — | 1 | 4.63 |
| CHEMBL486869 | — | — | 1 | 4.60 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 4.42 |
| CHEMBL487880 | — | — | 1 | 4.30 |
| CHEMBL443349 | — | — | 1 | 4.24 |
| CHEMBL487036 | — | — | 1 | 4.21 |
| CHEMBL454661 | — | — | 1 | - |
| CHEMBL128748 | DIMETHYLCURCUMIN | 2.0 | 1 | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | — | 1 | - |
| CHEMBL129913 | — | — | 1 | - |
| CHEMBL454662 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504623 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL487882 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL488901 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL210395 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL488900 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL454667 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL487035 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL486870 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL486851 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL179512 | DEMETHOXYCURCUMIN | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL487003 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL487881 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL486869 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL140 | CURCUMIN | IC50 | = | 38300.0 | nM | 4.42 |
| CHEMBL487880 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL443349 | — | IC50 | = | 57000.0 | nM | 4.24 |
| CHEMBL487036 | — | IC50 | = | 62200.0 | nM | 4.21 |
| CHEMBL454661 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL128748 | DIMETHYLCURCUMIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL105350 | BISDEMETHOXYCURCUMIN | IC50 | > | 100000.0 | nM | - |
| CHEMBL129913 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL454662 | — | IC50 | > | 100000.0 | nM | - |