Assay Detail
Functional
CHEMBL973586
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Antiviral activity against HCV 1b Con1 isolate in human Huh7.5 cells assessed as renilla luciferase activity after 3 days by RNA replicon assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 7.02 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230744 | — | — | 1 | 7.82 |
| CHEMBL509746 | — | — | 1 | 7.80 |
| CHEMBL515872 | — | — | 1 | 7.60 |
| CHEMBL514640 | — | — | 1 | 7.55 |
| CHEMBL490672 | FILIBUVIR | 3.0 | 1 | 7.39 |
| CHEMBL489476 | — | — | 1 | 7.37 |
| CHEMBL516051 | — | — | 1 | 7.23 |
| CHEMBL490671 | — | — | 1 | 7.17 |
| CHEMBL230743 | — | — | 1 | 7.13 |
| CHEMBL522458 | — | — | 1 | 7.00 |
| CHEMBL472913 | — | — | 1 | 6.82 |
| CHEMBL522658 | — | — | 1 | 6.72 |
| CHEMBL489295 | — | — | 1 | 6.51 |
| CHEMBL524103 | — | — | 1 | 6.48 |
| CHEMBL474322 | — | — | 1 | 6.23 |
| CHEMBL472914 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230744 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL509746 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL515872 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL514640 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL490672 | FILIBUVIR | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL489476 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL516051 | — | EC50 | = | 59.0 | nM | 7.23 |
| CHEMBL490671 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL230743 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL522458 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL472913 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL522658 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL489295 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL524103 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL474322 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL472914 | — | EC50 | = | 2900.0 | nM | 5.54 |