Assay Detail
Binding
CHEMBL973606
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Binding affinity to MC5 receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationship studies on a series of piperazinebenzylalcohols and their ketone and amine analogs as melanocortin-4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.13 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL460942 | — | — | 1 | 6.48 |
| CHEMBL511826 | — | — | 1 | 6.27 |
| CHEMBL454916 | — | — | 1 | 6.27 |
| CHEMBL454900 | — | — | 1 | 6.02 |
| CHEMBL513404 | — | — | 1 | 6.01 |
| CHEMBL471340 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL460942 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL511826 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL454916 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL454900 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL513404 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL471340 | — | Ki | = | 1800.0 | nM | 5.75 |