Assay Detail
Binding
CHEMBL973678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]rauwolscine from human adrenergic alpha 2C10 receptor expressed in mouse LTK- cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.82 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14638 | CIPROXIFAN | — | 1 | 7.37 |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | 6.90 |
| CHEMBL191703 | CONESSINE | 2.0 | 1 | 6.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14638 | CIPROXIFAN | Ki | = | 42.66 | nM | 7.37 |
| CHEMBL260374 | THIOPERAMIDE | Ki | = | 125.89 | nM | 6.90 |
| CHEMBL191703 | CONESSINE | Ki | = | 660.69 | nM | 6.18 |