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Assay Detail

CHEMBL973963

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of xanthine oxidase by spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Xanthine dehydrogenase/oxidase (CHEMBL1929)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

New guaianolides and xanthine oxidase inhibitory flavonols from ajania fruticulosa
Li H, Meng JC, Cheng CH, Higa T, Tanaka J, Tan RX.
J Nat Prod (1999) 62 : 1053 -1055
PubMed 10425142 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 4.50 4.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1467 ALLOPURINOL 4.0 1 4.62
CHEMBL487810 AXILLARIN 1 4.44
CHEMBL161957 SANTIN 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1467 ALLOPURINOL IC50 = 24200.0 nM 4.62
CHEMBL487810 AXILLARIN IC50 = 36000.0 nM 4.44
CHEMBL161957 SANTIN IC50 = 36500.0 nM 4.44