Assay Detail
Binding
CHEMBL974017
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Aurora A
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Small ribosomal subunit protein mS38 (CHEMBL5910) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 9.22 | 9.22 |
| IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 9.22 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL572878 | TOZASERTIB | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL601719 | CRIZOTINIB | IC50 | > | 10000.0 | nM | - |