Assay Detail

CHEMBL974181

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Functional

Cytotoxicity against pig LLC-PK1 cells after 96 hrs by MTT assay

ChEMBL ↗

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Target

LLC-PK1 (CHEMBL614577) ↗

Open DB target context

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Primary target LLC-PK1

CHEMBL614577

Anchored from Assay target.

Protein identity LLC-PK1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Sus scrofa
Cell Type	LLC-PK1
Confidence	1 — Organism
Curated By	Autocuration

Target

LLC-PK1 (CHEMBL614577) ↗

Type	CELL-LINE
Organism	Sus scrofa

Publication

Mycalamide D, a new cytotoxic amide from the New Zealand marine sponge Mycale species.

West LM, Northcote PT, Hood KA, Miller JH, Page MJ.
J Nat Prod (2000) 63 : 707 -709
PubMed 10843597 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.45	9.19

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL497451	MYCALAMIDE A	—	1	9.19
CHEMBL499036	MYCALAMIDE B	—	1	7.71

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL497451	MYCALAMIDE A	IC50	=	0.65	nM	9.19
CHEMBL499036	MYCALAMIDE B	IC50	=	19.43	nM	7.71