Assay Detail
Binding
CHEMBL974350
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Inhibition of MMP7
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115653 | CIPEMASTAT | 2.0 | 1 | 7.73 |
| CHEMBL514138 | CGS-27023A | — | 1 | 6.13 |
| CHEMBL466059 | — | — | 1 | 5.52 |
| CHEMBL440498 | CTS-1027 | 2.0 | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115653 | CIPEMASTAT | IC50 | = | 18.5 | nM | 7.73 |
| CHEMBL514138 | CGS-27023A | IC50 | = | 736.0 | nM | 6.13 |
| CHEMBL466059 | — | IC50 | = | 3025.0 | nM | 5.52 |
| CHEMBL440498 | CTS-1027 | IC50 | = | 3100.0 | nM | 5.51 |