Assay Detail
Binding
CHEMBL974405
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-fused human recombinant CK2alpha expressed in Escherichia coli HMS174 (DE3)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.09 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | 2.0 | 1 | 7.40 |
| CHEMBL92361 | — | — | 1 | 6.41 |
| CHEMBL28 | APIGENIN | — | 1 | 6.10 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | — | 1 | 6.05 |
| CHEMBL289277 | EMODIN | — | 1 | 5.70 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6246 | ELLAGIC ACID | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL92361 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL28 | APIGENIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL177820 | TETRABROMOBENZOTRIAZOLE | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL289277 | EMODIN | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 13000.0 | nM | 4.89 |