Assay Detail
Binding
CHEMBL974429
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Inhibition of verapamil-stimulated ATPase activity of human histidine10-tagged MDR1 expressed in BHK cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | BHK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rhodamine inhibitors of P-glycoprotein: an amide/thioamide "switch" for ATPase activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.29 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450642 | — | — | 1 | 6.17 |
| CHEMBL490121 | — | — | 1 | 5.64 |
| CHEMBL522826 | — | — | 1 | 5.28 |
| CHEMBL491577 | — | — | 1 | 5.17 |
| CHEMBL495469 | — | — | 1 | 5.10 |
| CHEMBL492602 | — | — | 1 | 5.05 |
| CHEMBL522966 | — | — | 1 | 4.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450642 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL490121 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL522826 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL491577 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL495469 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL492602 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL522966 | — | IC50 | = | 23600.0 | nM | 4.63 |