Assay Detail
Binding
CHEMBL974566
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Inhibition of [14C]glutamate uptake at human EAAT3 expressed in african green monkey COS1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and preliminary pharmacological evaluation of novel derivatives of L-beta-threo-benzylaspartate as inhibitors of the neuronal glutamate transporter EAAT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.22 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1790042 | — | — | 1 | 5.32 |
| CHEMBL1790043 | — | — | 1 | 5.19 |
| CHEMBL79140 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1790042 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1790043 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL79140 | — | IC50 | = | 7000.0 | nM | 5.16 |