Assay Detail
Binding
CHEMBL974648
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of lipoxygenase 5 product formation from endogenous substrate in Calcium and ionophore-stimulated polymorphonuclear leukocyte
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Workup-dependent formation of 5-lipoxygenase inhibitory boswellic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL513407 | — | — | 1 | 6.12 |
| CHEMBL237111 | AKBA | -1.0 | 1 | 5.57 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | — | 1 | 5.52 |
| CHEMBL471066 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL513407 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL237111 | AKBA | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL471066 | — | IC50 | - | — | - |