Assay Detail
Binding
CHEMBL974649
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin microtubule disassembly
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationship of polyisoprenyl benzophenones from Garcinia pyrifera on the tubulin/microtubule system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.94 | 6.30 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.30 |
| CHEMBL447153 | GUTTIFERONE E | — | 1 | 5.82 |
| CHEMBL510949 | XANTHOCHYMOL | — | 1 | 5.70 |
| CHEMBL451601 | OCTAHYDROXANTHOCHYMOL | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL447153 | GUTTIFERONE E | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL510949 | XANTHOCHYMOL | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL451601 | OCTAHYDROXANTHOCHYMOL | Activity | - | — | - |