Assay Detail
Functional
CHEMBL974738
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Inhibition of IL-1-beta-induced ICAM1 expression in human A549 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Guaianolides as immunomodulators. Synthesis and biological activities of dehydrocostus lactone, mokko lactone, eremanthin, and their derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.97 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507833 | — | — | 1 | 5.22 |
| CHEMBL451970 | — | — | 1 | 5.16 |
| CHEMBL523903 | — | — | 1 | 5.10 |
| CHEMBL508639 | — | — | 1 | 5.00 |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | — | 1 | 5.00 |
| CHEMBL451364 | EREMANTHIN | — | 1 | 4.34 |
| CHEMBL509641 | — | — | 1 | - |
| CHEMBL453533 | — | — | 1 | - |
| CHEMBL509640 | — | — | 1 | - |
| CHEMBL453274 | MOKKO LACTONE | — | 1 | - |
| CHEMBL453534 | — | — | 1 | - |
| CHEMBL451972 | — | — | 1 | - |
| CHEMBL508640 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507833 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL451970 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL523903 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL508639 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL88985 | DEHYDROCOSTUSLACTONE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL451364 | EREMANTHIN | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL509641 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL453533 | — | IC50 | = | 253000.0 | nM | - |
| CHEMBL509640 | — | IC50 | = | 504000.0 | nM | - |
| CHEMBL453274 | MOKKO LACTONE | IC50 | = | 251000.0 | nM | - |
| CHEMBL453534 | — | IC50 | = | 136000.0 | nM | - |
| CHEMBL451972 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL508640 | — | IC50 | = | 442000.0 | nM | - |