Assay Detail
Binding
CHEMBL975012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from rat recombinant dopamine D3 receptor expressed in SF9 cells
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and neuropharmacological evaluation of 2-aryl- and alkylapomorphines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.43 | 8.43 |
| Ki | 6 | 7.74 | 8.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL458579 | — | — | 2 | 8.75 |
| CHEMBL458397 | — | — | 2 | 8.11 |
| CHEMBL465696 | — | — | 2 | 7.65 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | 4.0 | 2 | 7.44 |
| CHEMBL507567 | — | — | 2 | 7.40 |
| CHEMBL3216443 | — | — | 2 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL458579 | — | Ki | = | 1.78 | nM | 8.75 |
| CHEMBL458579 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL458397 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL458397 | — | IC50 | = | 14.7 | nM | 7.83 |
| CHEMBL465696 | — | Ki | = | 22.3 | nM | 7.65 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | Ki | = | 36.4 | nM | 7.44 |
| CHEMBL507567 | — | Ki | = | 40.1 | nM | 7.40 |
| CHEMBL465696 | — | IC50 | = | 49.4 | nM | 7.31 |
| CHEMBL3187985 | APOMORPHINE HYDROCHLORIDE | IC50 | = | 69.5 | nM | 7.16 |
| CHEMBL3216443 | — | Ki | = | 78.4 | nM | 7.11 |
| CHEMBL507567 | — | IC50 | = | 82.6 | nM | 7.08 |
| CHEMBL3216443 | — | IC50 | = | 178.0 | nM | 6.75 |