Assay Detail
Binding
CHEMBL975042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protection of human pregnane X receptor against proteolytic digestion in presence of trypsin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 1 group I member 2 (CHEMBL3401) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-1H-benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.27 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL463678 | — | — | 1 | 8.10 |
| CHEMBL464497 | — | — | 1 | 8.09 |
| CHEMBL513946 | — | — | 1 | 6.80 |
| CHEMBL457271 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL463678 | — | EC50 | = | 8.04 | nM | 8.10 |
| CHEMBL464497 | — | EC50 | = | 8.05 | nM | 8.09 |
| CHEMBL513946 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL457271 | — | EC50 | = | 809.0 | nM | 6.09 |