Assay Detail
Functional
CHEMBL975179
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Antiviral activity against HCV 1b Con1 in 2209-23 cells after 72 hrs by luciferase based replicon assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | 2209-23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) and identification of a novel active 5'-triphosphate species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.22 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223482 | — | — | 1 | 6.22 |
| CHEMBL510394 | — | — | 1 | - |
| CHEMBL373691 | PSI-6130-TP | -1.0 | 1 | - |
| CHEMBL486231 | GS-461203 | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223482 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL510394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL373691 | PSI-6130-TP | IC50 | - | — | - | |
| CHEMBL486231 | GS-461203 | IC50 | - | — | - |