Assay Detail
Functional
CHEMBL975254
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Cytotoxicity against human HeLa cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationships of diverse annonaceous acetogenins against human tumor cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.37 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL506139 | — | — | 1 | 8.89 |
| CHEMBL41177 | SQUAMOCIN | — | 1 | 8.01 |
| CHEMBL484529 | ISODESACETYLUVARICIN | — | 1 | 7.89 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.80 |
| CHEMBL452936 | Squamocin-D | — | 1 | 7.62 |
| CHEMBL606053 | ASIMICIN | — | 1 | 7.57 |
| CHEMBL447119 | Squamostatin-A | — | 1 | 7.48 |
| CHEMBL448616 | Squamostatin-D | — | 1 | 7.42 |
| CHEMBL503744 | DEACETYLUVARICIN | — | 1 | 6.80 |
| CHEMBL448377 | Squamostatin-E | — | 1 | 6.57 |
| CHEMBL499780 | Squamostatin-B | — | 1 | 6.42 |
| CHEMBL447802 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL506139 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL41177 | SQUAMOCIN | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL484529 | ISODESACETYLUVARICIN | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL452936 | Squamocin-D | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL606053 | ASIMICIN | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL447119 | Squamostatin-A | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL448616 | Squamostatin-D | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL503744 | DEACETYLUVARICIN | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL448377 | Squamostatin-E | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL499780 | Squamostatin-B | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL447802 | — | IC50 | = | 1000.0 | nM | 6.00 |