Assay Detail
Binding
CHEMBL975287
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Inhibition of human recombinant rennin in human plasma assessed as accumulation of angiotensin 1 using human tetradecapeptide by immunoassay
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 6.92 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL113841 | ZANKIREN | 2.0 | 1 | 8.96 |
| CHEMBL508205 | — | — | 1 | 8.15 |
| CHEMBL443192 | — | — | 1 | 8.06 |
| CHEMBL504443 | — | — | 1 | 8.04 |
| CHEMBL509480 | — | — | 1 | 7.75 |
| CHEMBL449638 | — | — | 1 | 7.72 |
| CHEMBL505635 | — | — | 1 | 7.64 |
| CHEMBL454732 | — | — | 1 | 7.62 |
| CHEMBL443469 | — | — | 1 | 7.60 |
| CHEMBL444146 | — | — | 1 | 7.58 |
| CHEMBL443718 | — | — | 1 | 7.54 |
| CHEMBL447097 | — | — | 1 | 7.54 |
| CHEMBL503443 | — | — | 1 | 7.47 |
| CHEMBL509903 | — | — | 1 | 7.44 |
| CHEMBL506268 | — | — | 1 | 7.40 |
| CHEMBL451603 | — | — | 1 | 7.39 |
| CHEMBL452147 | — | — | 1 | 7.30 |
| CHEMBL475671 | — | — | 1 | 7.27 |
| CHEMBL503710 | — | — | 1 | 7.25 |
| CHEMBL448175 | — | — | 1 | 7.25 |
| CHEMBL507560 | — | — | 1 | 7.22 |
| CHEMBL500205 | — | — | 1 | 7.07 |
| CHEMBL502200 | — | — | 1 | 7.07 |
| CHEMBL500811 | — | — | 1 | 7.06 |
| CHEMBL449779 | — | — | 1 | 7.00 |
| CHEMBL446741 | — | — | 1 | 6.92 |
| CHEMBL505760 | — | — | 1 | 6.91 |
| CHEMBL504403 | — | — | 1 | 6.89 |
| CHEMBL508158 | — | — | 1 | 6.89 |
| CHEMBL447651 | — | — | 1 | 6.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL113841 | ZANKIREN | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL508205 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL443192 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL504443 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL509480 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL449638 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL505635 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL454732 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL443469 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL444146 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL443718 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL447097 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL503443 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL509903 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL506268 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL451603 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL452147 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL475671 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL503710 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL448175 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL507560 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL500205 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL502200 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL500811 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL449779 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL446741 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL505760 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL504403 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL508158 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL447651 | — | IC50 | = | 167.0 | nM | 6.78 |
| CHEMBL508748 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL454711 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL470882 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL449458 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL503129 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL501586 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL452191 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL470878 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL510822 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL507083 | — | IC50 | = | 456.0 | nM | 6.34 |
| CHEMBL449505 | — | IC50 | = | 582.0 | nM | 6.24 |
| CHEMBL447104 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL501912 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL453778 | — | IC50 | = | 694.0 | nM | 6.16 |
| CHEMBL467850 | — | IC50 | = | 699.0 | nM | 6.16 |
| CHEMBL509242 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL502925 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL510710 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL511054 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL455047 | — | IC50 | = | 3600.0 | nM | 5.44 |