Assay Detail
Binding
CHEMBL975554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]nitrendipine from voltage-dependent calcium channel in rat brain cortex by scintillation counting
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anticonvulsant activity of some xanthone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.68 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 9.00 |
| CHEMBL108 | CARBAMAZEPINE | 4.0 | 1 | 5.92 |
| CHEMBL466964 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL108 | CARBAMAZEPINE | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL466964 | — | EC50 | = | 7600.0 | nM | 5.12 |