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Assay Detail

CHEMBL975558

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant MAOB
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] B (CHEMBL2039)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Fluorinated phenylcyclopropylamines. Part 5: Effects of electron-withdrawing or -donating aryl substituents on the inhibition of monoamine oxidases A and B by 2-aryl-2-fluoro-cyclopropylamines.
Hruschka S, Rosen TC, Yoshida S, Kirk KL, Fröhlich R, Wibbeling B, Haufe G.
Bioorg Med Chem (2008) 16 : 7148 -7166
PubMed 18640844 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 4.94 5.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL466770 1 5.43
CHEMBL460269 1 5.32
CHEMBL447729 1 5.31
CHEMBL462630 1 5.29
CHEMBL468597 1 5.27
CHEMBL455782 1 5.19
CHEMBL446059 1 5.15
CHEMBL446771 1 5.00
CHEMBL468852 1 4.89
CHEMBL468854 1 4.75
CHEMBL1179 1 4.72
CHEMBL467794 1 4.72
CHEMBL466769 1 4.72
CHEMBL511601 1 4.70
CHEMBL509322 1 4.62
CHEMBL450413 1 4.52
CHEMBL469024 1 4.43
CHEMBL468855 1 -
CHEMBL500248 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL466770 IC50 = 3700.0 nM 5.43
CHEMBL460269 IC50 = 4800.0 nM 5.32
CHEMBL447729 IC50 = 4900.0 nM 5.31
CHEMBL462630 IC50 = 5100.0 nM 5.29
CHEMBL468597 IC50 = 5400.0 nM 5.27
CHEMBL455782 IC50 = 6400.0 nM 5.19
CHEMBL446059 IC50 = 7100.0 nM 5.15
CHEMBL446771 IC50 = 10000.0 nM 5.00
CHEMBL468852 IC50 = 13000.0 nM 4.89
CHEMBL468854 IC50 = 18000.0 nM 4.75
CHEMBL1179 IC50 = 19000.0 nM 4.72
CHEMBL467794 IC50 = 19000.0 nM 4.72
CHEMBL466769 IC50 = 19000.0 nM 4.72
CHEMBL511601 IC50 = 20000.0 nM 4.70
CHEMBL509322 IC50 = 24000.0 nM 4.62
CHEMBL450413 IC50 = 30000.0 nM 4.52
CHEMBL469024 IC50 = 37000.0 nM 4.43
CHEMBL468855 IC50 = 230000.0 nM -
CHEMBL500248 IC50 = 470000.0 nM -