Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL975644

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human KB cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Autocuration

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

Cytotoxic monotetrahydrofuran acetogenins from Disepalum plagioneurum.
Eparvier V, Nguyen VH, Thoison O, Martin MT, Sévenet T, Guéritte F.
J Nat Prod (2006) 69 : 1289 -1294
PubMed 16989521 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.16 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.70
CHEMBL509724 PLAGIONICIN A 1 8.70
CHEMBL505387 PLAGIONEURIN A 1 8.62
CHEMBL447872 PLAGIONEURIN E 1 8.59
CHEMBL451272 PLAGIONEURIN D 1 8.55
CHEMBL454758 PLAGIONICIN C 1 8.22
CHEMBL503560 PLAGIONEURIN B 1 8.19
CHEMBL451056 PLAGIONEURIN C 1 7.58
CHEMBL446728 PLAGIONICIN D 1 7.58
CHEMBL504881 PLAGIONICIN B 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.2 nM 9.70
CHEMBL509724 PLAGIONICIN A IC50 = 2.0 nM 8.70
CHEMBL505387 PLAGIONEURIN A IC50 = 2.4 nM 8.62
CHEMBL447872 PLAGIONEURIN E IC50 = 2.6 nM 8.59
CHEMBL451272 PLAGIONEURIN D IC50 = 2.8 nM 8.55
CHEMBL454758 PLAGIONICIN C IC50 = 6.0 nM 8.22
CHEMBL503560 PLAGIONEURIN B IC50 = 6.5 nM 8.19
CHEMBL451056 PLAGIONEURIN C IC50 = 26.0 nM 7.58
CHEMBL446728 PLAGIONICIN D IC50 = 26.0 nM 7.58
CHEMBL504881 PLAGIONICIN B IC50 = 1400.0 nM 5.85