Assay Detail
Binding
CHEMBL975646
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]RTI-55 from human NET expressed in MDCK cell membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent noradrenaline transporter (CHEMBL222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antidepressant principles of the roots of Polygala tenuifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.26 | 9.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 9.03 |
| CHEMBL462805 | POLYGALATENOSIDE B | — | 1 | 5.22 |
| CHEMBL463000 | POLYGALATENOSIDE A | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72 | DESIPRAMINE | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL462805 | POLYGALATENOSIDE B | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL463000 | POLYGALATENOSIDE A | IC50 | = | 30000.0 | nM | 4.52 |