Assay Detail
Binding
CHEMBL975907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HIV reverse transcriptase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: introducing a diketoacid functionality into delavirdine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.14 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495410 | — | — | 1 | 8.23 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 7.44 |
| CHEMBL493409 | — | — | 1 | 6.92 |
| CHEMBL494757 | — | — | 1 | 5.96 |
| CHEMBL494758 | — | — | 1 | - |
| CHEMBL494420 | — | — | 1 | - |
| CHEMBL493220 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495410 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL493409 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL494757 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL494758 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL494420 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL493220 | — | IC50 | > | 100000.0 | nM | - |