Assay Detail
Binding
CHEMBL976148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]dofetilide human ERG expressed in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
8-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors--part II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.67 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490417 | — | — | 1 | 7.20 |
| CHEMBL512724 | — | — | 1 | 7.00 |
| CHEMBL511279 | — | — | 1 | 6.40 |
| CHEMBL470849 | — | — | 1 | 6.20 |
| CHEMBL522257 | — | — | 1 | 6.10 |
| CHEMBL469568 | — | — | 1 | 5.80 |
| CHEMBL469995 | — | — | 1 | 5.80 |
| CHEMBL513715 | — | — | 1 | 5.60 |
| CHEMBL470217 | — | — | 1 | 5.50 |
| CHEMBL513875 | — | — | 1 | 5.50 |
| CHEMBL472289 | — | — | 1 | 5.50 |
| CHEMBL469345 | — | — | 1 | 5.40 |
| CHEMBL469374 | — | — | 1 | 5.40 |
| CHEMBL469567 | — | — | 1 | 5.30 |
| CHEMBL469375 | — | — | 1 | 5.30 |
| CHEMBL469376 | — | — | 1 | 5.20 |
| CHEMBL469589 | — | — | 1 | 5.20 |
| CHEMBL472290 | — | — | 1 | 5.10 |
| CHEMBL511815 | — | — | 1 | 5.00 |
| CHEMBL471047 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490417 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL512724 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL511279 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL470849 | — | Ki | = | 630.96 | nM | 6.20 |
| CHEMBL522257 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL469568 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL469995 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL513715 | — | Ki | = | 2511.89 | nM | 5.60 |
| CHEMBL470217 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL513875 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL472289 | — | Ki | = | 3162.28 | nM | 5.50 |
| CHEMBL469345 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL469374 | — | Ki | = | 3981.07 | nM | 5.40 |
| CHEMBL469567 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL469375 | — | Ki | = | 5011.87 | nM | 5.30 |
| CHEMBL469376 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL469589 | — | Ki | = | 6309.57 | nM | 5.20 |
| CHEMBL472290 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL511815 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL471047 | — | Ki | = | 12589.25 | nM | 4.90 |