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Assay Detail

CHEMBL976198

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]DPCPX from human recombinant adenosine A2B receptor expressed in HEK293 cells by beta scintillation counter
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HEK293
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Adenosine receptor A2b (CHEMBL255)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.
Fernández F, Caamaño O, Isabel Nieto M, López C, García-Mera X, Stefanachi A, Nicolotti O, Isabel Loza M, Brea J, Esteve C, Segarra V, Vidal B, Carotti A.
Bioorg Med Chem (2009) 17 : 3618 -3629
PubMed 19398343 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 7.95 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL513681 1 9.10
CHEMBL466035 1 8.77
CHEMBL512276 1 8.70
CHEMBL469136 1 8.68
CHEMBL512290 1 8.55
CHEMBL468506 1 8.49
CHEMBL466453 1 8.23
CHEMBL466021 1 8.15
CHEMBL467271 1 8.11
CHEMBL469119 1 8.02
CHEMBL468295 1 8.00
CHEMBL513135 1 7.94
CHEMBL468920 1 7.86
CHEMBL511714 1 7.79
CHEMBL452454 1 7.62
CHEMBL466828 1 7.37
CHEMBL468296 1 7.09
CHEMBL468306 1 6.30
CHEMBL467270 1 6.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL513681 Ki = 0.8 nM 9.10
CHEMBL466035 Ki = 1.7 nM 8.77
CHEMBL512276 Ki = 2.0 nM 8.70
CHEMBL469136 Ki = 2.1 nM 8.68
CHEMBL512290 Ki = 2.8 nM 8.55
CHEMBL468506 Ki = 3.2 nM 8.49
CHEMBL466453 Ki = 5.9 nM 8.23
CHEMBL466021 Ki = 7.1 nM 8.15
CHEMBL467271 Ki = 7.8 nM 8.11
CHEMBL469119 Ki = 9.5 nM 8.02
CHEMBL468295 Ki = 10.0 nM 8.00
CHEMBL513135 Ki = 11.5 nM 7.94
CHEMBL468920 Ki = 13.8 nM 7.86
CHEMBL511714 Ki = 16.2 nM 7.79
CHEMBL452454 Ki = 24.0 nM 7.62
CHEMBL466828 Ki = 42.7 nM 7.37
CHEMBL468296 Ki = 81.3 nM 7.09
CHEMBL468306 Ki = 501.0 nM 6.30
CHEMBL467270 Ki = 602.0 nM 6.22