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Assay Detail

CHEMBL976250

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Escherichia coli N5-CAIR synthetase by phosphate assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Escherichia coli
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening.
Firestine SM, Paritala H, McDonnell JE, Thoden JB, Holden HM.
Bioorg Med Chem (2009) 17 : 3317 -3323
PubMed 19362848 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 4.85 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL511570 1 5.64
CHEMBL467527 1 5.25
CHEMBL447748 1 5.11
CHEMBL467526 1 5.06
CHEMBL467285 1 5.00
CHEMBL445719 1 4.98
CHEMBL467735 1 4.77
CHEMBL443361 1 4.77
CHEMBL116649 1 4.72
CHEMBL511565 1 4.70
CHEMBL452118 1 4.66
CHEMBL466464 1 4.64
CHEMBL467080 1 4.43
CHEMBL467081 1 4.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL511570 IC50 = 2300.0 nM 5.64
CHEMBL467527 IC50 = 5600.0 nM 5.25
CHEMBL447748 IC50 = 7800.0 nM 5.11
CHEMBL467526 IC50 = 8700.0 nM 5.06
CHEMBL467285 IC50 = 10000.0 nM 5.00
CHEMBL445719 IC50 = 10500.0 nM 4.98
CHEMBL467735 IC50 = 17000.0 nM 4.77
CHEMBL443361 IC50 = 17000.0 nM 4.77
CHEMBL116649 IC50 = 19000.0 nM 4.72
CHEMBL511565 IC50 = 20000.0 nM 4.70
CHEMBL452118 IC50 = 22000.0 nM 4.66
CHEMBL466464 IC50 = 23000.0 nM 4.64
CHEMBL467080 IC50 = 37000.0 nM 4.43
CHEMBL467081 IC50 = 69000.0 nM 4.16