Assay Detail
Functional
CHEMBL976272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytostatic activity against human H460 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
The novel primaquine derivatives of N-alkyl, cycloalkyl or aryl urea: synthesis, cytostatic and antiviral activity evaluations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.42 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455392 | — | — | 1 | 4.68 |
| CHEMBL455416 | — | — | 1 | 4.60 |
| CHEMBL528548 | — | — | 1 | 4.52 |
| CHEMBL508468 | — | — | 1 | 4.32 |
| CHEMBL488856 | — | — | 1 | 4.27 |
| CHEMBL455151 | — | — | 1 | 4.11 |
| CHEMBL455150 | PRIMAQUINE BENZOTRIAZOLIDE | — | 1 | - |
| CHEMBL455417 | — | — | 1 | - |
| CHEMBL455391 | — | — | 1 | - |
| CHEMBL453609 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455392 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL455416 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL528548 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL508468 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL488856 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL455151 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL455150 | PRIMAQUINE BENZOTRIAZOLIDE | IC50 | > | 100000.0 | nM | - |
| CHEMBL455417 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL455391 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL453609 | — | IC50 | > | 100000.0 | nM | - |