Assay Detail
Functional
CHEMBL976276
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Cytotoxicity against human K562 cells transfected with wild-type Bcr-Abl
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel N9-arenethenyl purines as potent dual Src/Abl tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.06 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL518166 | — | — | 1 | 8.07 |
| CHEMBL510893 | — | — | 1 | 7.98 |
| CHEMBL517256 | — | — | 1 | 7.80 |
| CHEMBL459877 | — | — | 1 | 7.64 |
| CHEMBL509941 | — | — | 1 | 7.63 |
| CHEMBL461767 | — | — | 1 | 7.57 |
| CHEMBL461768 | — | — | 1 | 7.55 |
| CHEMBL516498 | — | — | 1 | 7.39 |
| CHEMBL509002 | — | — | 1 | 7.28 |
| CHEMBL455384 | — | — | 1 | 7.25 |
| CHEMBL451790 | — | — | 1 | 7.05 |
| CHEMBL454611 | — | — | 1 | 6.96 |
| CHEMBL488840 | — | — | 1 | 6.96 |
| CHEMBL528330 | — | — | 1 | 6.94 |
| CHEMBL454873 | — | — | 1 | 6.66 |
| CHEMBL460074 | — | — | 1 | 6.65 |
| CHEMBL452563 | — | — | 1 | 6.45 |
| CHEMBL454872 | — | — | 1 | 6.43 |
| CHEMBL454868 | — | — | 1 | 6.02 |
| CHEMBL520540 | — | — | 1 | 6.02 |
| CHEMBL510891 | — | — | 1 | 5.86 |
| CHEMBL488659 | — | — | 1 | - |
| CHEMBL488658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL518166 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL510893 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL517256 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL459877 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL509941 | — | IC50 | = | 23.5 | nM | 7.63 |
| CHEMBL461767 | — | IC50 | = | 26.7 | nM | 7.57 |
| CHEMBL461768 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL516498 | — | IC50 | = | 40.6 | nM | 7.39 |
| CHEMBL509002 | — | IC50 | = | 52.4 | nM | 7.28 |
| CHEMBL455384 | — | IC50 | = | 55.7 | nM | 7.25 |
| CHEMBL451790 | — | IC50 | = | 89.1 | nM | 7.05 |
| CHEMBL454611 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL488840 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL528330 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL454873 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL460074 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL452563 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL454872 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL454868 | — | IC50 | = | 954.0 | nM | 6.02 |
| CHEMBL520540 | — | IC50 | = | 964.0 | nM | 6.02 |
| CHEMBL510891 | — | IC50 | = | 1394.0 | nM | 5.86 |
| CHEMBL488659 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL488658 | — | IC50 | > | 1000.0 | nM | - |