Assay Detail
Binding
CHEMBL976330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human cloned CA9 catalytic domain by stopped-flow CO2 hydration method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.52 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476937 | — | — | 1 | 7.75 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.60 |
| CHEMBL286738 | IROSUSTAT | 2.0 | 1 | 7.47 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476937 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL286738 | IROSUSTAT | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 58.0 | nM | 7.24 |