Assay Detail
Binding
CHEMBL976441
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Inhibition of HDAC1 after 17 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.85 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.40 |
| CHEMBL468595 | — | — | 1 | 7.68 |
| CHEMBL467793 | — | — | 1 | 7.25 |
| CHEMBL468842 | — | — | 1 | 7.19 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.02 |
| CHEMBL469274 | — | — | 1 | 7.00 |
| CHEMBL513160 | — | — | 1 | 6.91 |
| CHEMBL511749 | — | — | 1 | 6.57 |
| CHEMBL468841 | — | — | 1 | 6.44 |
| CHEMBL467792 | — | — | 1 | 6.20 |
| CHEMBL467998 | — | — | 1 | 6.19 |
| CHEMBL446512 | — | — | 1 | 6.14 |
| CHEMBL469275 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL468595 | — | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL467793 | — | IC50 | = | 56.3 | nM | 7.25 |
| CHEMBL468842 | — | IC50 | = | 64.5 | nM | 7.19 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL469274 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL513160 | — | IC50 | = | 124.0 | nM | 6.91 |
| CHEMBL511749 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL468841 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL467792 | — | IC50 | = | 628.0 | nM | 6.20 |
| CHEMBL467998 | — | IC50 | = | 644.0 | nM | 6.19 |
| CHEMBL446512 | — | IC50 | = | 716.0 | nM | 6.14 |
| CHEMBL469275 | — | IC50 | = | 826.0 | nM | 6.08 |