Assay Detail
Binding
CHEMBL976442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC2 after 17 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.48 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.85 |
| CHEMBL468595 | — | — | 1 | 7.25 |
| CHEMBL513160 | — | — | 1 | 6.88 |
| CHEMBL468842 | — | — | 1 | 6.88 |
| CHEMBL467793 | — | — | 1 | 6.83 |
| CHEMBL469274 | — | — | 1 | 6.62 |
| CHEMBL511749 | — | — | 1 | 6.60 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.55 |
| CHEMBL468841 | — | — | 1 | 5.98 |
| CHEMBL467998 | — | — | 1 | 5.77 |
| CHEMBL467792 | — | — | 1 | 5.76 |
| CHEMBL446512 | — | — | 1 | 5.71 |
| CHEMBL469275 | — | — | 1 | 5.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL468595 | — | IC50 | = | 56.7 | nM | 7.25 |
| CHEMBL513160 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL468842 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL467793 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL469274 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL511749 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL468841 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL467998 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL467792 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL446512 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL469275 | — | IC50 | = | 2980.0 | nM | 5.53 |