Assay Detail
Binding
CHEMBL976444
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Inhibition of HDAC8 after 17 hrs
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.47 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468595 | — | — | 1 | 6.03 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.94 |
| CHEMBL468841 | — | — | 1 | 5.55 |
| CHEMBL513160 | — | — | 1 | 5.48 |
| CHEMBL467793 | — | — | 1 | 5.46 |
| CHEMBL446512 | — | — | 1 | 5.46 |
| CHEMBL467998 | — | — | 1 | 5.45 |
| CHEMBL467792 | — | — | 1 | 5.44 |
| CHEMBL468842 | — | — | 1 | 5.31 |
| CHEMBL469275 | — | — | 1 | 5.24 |
| CHEMBL511749 | — | — | 1 | 5.16 |
| CHEMBL469274 | — | — | 1 | 5.09 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468595 | — | IC50 | = | 938.0 | nM | 6.03 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL468841 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL513160 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL467793 | — | IC50 | = | 3458.0 | nM | 5.46 |
| CHEMBL446512 | — | IC50 | = | 3430.0 | nM | 5.46 |
| CHEMBL467998 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL467792 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL468842 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL469275 | — | IC50 | = | 5810.0 | nM | 5.24 |
| CHEMBL511749 | — | IC50 | = | 6851.0 | nM | 5.16 |
| CHEMBL469274 | — | IC50 | = | 8104.0 | nM | 5.09 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 1.38 | nM | - |