Assay Detail
Functional
CHEMBL976447
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Antiproliferative activity against human BxPC3 cells after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BXPC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.20 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL468595 | — | — | 1 | 6.16 |
| CHEMBL467793 | — | — | 1 | 6.10 |
| CHEMBL511749 | — | — | 1 | 6.00 |
| CHEMBL469274 | — | — | 1 | 6.00 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.30 |
| CHEMBL468842 | — | — | 1 | 5.22 |
| CHEMBL513160 | — | — | 1 | 5.16 |
| CHEMBL467792 | — | — | 1 | 4.60 |
| CHEMBL467998 | — | — | 1 | 4.55 |
| CHEMBL468841 | — | — | 1 | 4.48 |
| CHEMBL469275 | — | — | 1 | 4.44 |
| CHEMBL446512 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL468595 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL467793 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL511749 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL469274 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL468842 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL513160 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL467792 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL467998 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL468841 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL469275 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL446512 | — | IC50 | = | 38000.0 | nM | 4.42 |