Assay Detail
Binding
CHEMBL976462
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Inhibition of recombinant HCV 1b NS5B deltac21 RNA polymerase by scintillator counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.20 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL522710 | — | — | 1 | 6.02 |
| CHEMBL492769 | — | — | 1 | 5.82 |
| CHEMBL492772 | — | — | 1 | 5.70 |
| CHEMBL492770 | — | — | 1 | 5.34 |
| CHEMBL492768 | — | — | 1 | 5.08 |
| CHEMBL492571 | — | — | 1 | 4.55 |
| CHEMBL492771 | — | — | 1 | 4.55 |
| CHEMBL499444 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL522710 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL492769 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL492772 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL492770 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL492768 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL492571 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL492771 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL499444 | — | IC50 | = | 30000.0 | nM | 4.52 |