Assay Detail
Functional
CHEMBL976465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HCV subgenomic replicon harboring NS5B gene transfected in human Huh7 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Effects of the aryl linker and the aromatic substituent on the anti-HCV activities of aryl diketoacid (ADK) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.36 | 6.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492772 | — | — | 1 | 6.27 |
| CHEMBL492768 | — | — | 1 | 6.18 |
| CHEMBL522710 | — | — | 1 | 6.09 |
| CHEMBL492769 | — | — | 1 | 5.51 |
| CHEMBL492571 | — | — | 1 | 4.55 |
| CHEMBL492770 | — | — | 1 | 4.52 |
| CHEMBL499444 | — | — | 1 | 4.40 |
| CHEMBL492771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492772 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL492768 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL522710 | — | EC50 | = | 820.0 | nM | 6.09 |
| CHEMBL492769 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL492571 | — | EC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL492770 | — | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL499444 | — | EC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL492771 | — | EC50 | > | 50000.0 | nM | - |