Assay Detail

CHEMBL976492

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Selectivity ratio for human adrenergic alpha 2C4 receptor over human H3 receptor

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.

Zhao C, Sun M, Bennani YL, Gopalakrishnan SM, Witte DG, Miller TR, Krueger KM, Browman KE, Thiffault C, Wetter J, Marsh KC, Hancock AA, Esbenshade TA, Cowart MD.
J Med Chem (2008) 51 : 5423 -5430
PubMed 18683917 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	7.57	8.70

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL191703	CONESSINE	2.0	1	8.70
CHEMBL451821	—	—	1	6.43

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL191703	CONESSINE	Ki	=	2.0	nM	8.70
CHEMBL451821	—	Ki	=	370.0	nM	6.43