Assay Detail
Functional
CHEMBL976508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at mouse CCK1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.71 | 10.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504114 | — | — | 1 | 10.47 |
| CHEMBL450105 | — | — | 1 | 9.96 |
| CHEMBL509464 | — | — | 1 | 9.96 |
| CHEMBL504406 | — | — | 1 | 9.89 |
| CHEMBL504861 | — | — | 1 | 9.52 |
| CHEMBL508004 | — | — | 1 | 9.30 |
| CHEMBL505727 | — | — | 1 | 8.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504114 | — | EC50 | = | 0.034 | nM | 10.47 |
| CHEMBL450105 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL509464 | — | EC50 | = | 0.11 | nM | 9.96 |
| CHEMBL504406 | — | EC50 | = | 0.13 | nM | 9.89 |
| CHEMBL504861 | — | EC50 | = | 0.3 | nM | 9.52 |
| CHEMBL508004 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL505727 | — | EC50 | = | 1.3 | nM | 8.89 |