Assay Detail
Functional
CHEMBL977103
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Growth inhibition of human MIAPaCa2 cells after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.74 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL475258 | — | — | 1 | 5.52 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.00 |
| CHEMBL451477 | — | — | 1 | 4.77 |
| CHEMBL503357 | — | — | 1 | 4.75 |
| CHEMBL475578 | — | — | 1 | 4.30 |
| CHEMBL473232 | — | — | 1 | 4.10 |
| CHEMBL503034 | — | — | 1 | - |
| CHEMBL38107 | — | — | 1 | - |
| CHEMBL465176 | HYDRACYCLUR | — | 1 | - |
| CHEMBL36394 | — | — | 1 | - |
| CHEMBL37731 | IODACYCLUR | — | 1 | - |
| CHEMBL208654 | IODMETACYCLUR | — | 1 | - |
| CHEMBL500883 | — | — | 1 | - |
| CHEMBL511046 | — | — | 1 | - |
| CHEMBL472603 | — | — | 1 | - |
| CHEMBL499820 | N4-hydroxycytosine | — | 1 | - |
| CHEMBL472604 | — | — | 1 | - |
| CHEMBL470521 | — | — | 1 | - |
| CHEMBL210951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL475258 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL451477 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL503357 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL475578 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL473232 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL503034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL38107 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL465176 | HYDRACYCLUR | IC50 | > | 100000.0 | nM | - |
| CHEMBL36394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL37731 | IODACYCLUR | IC50 | > | 100000.0 | nM | - |
| CHEMBL208654 | IODMETACYCLUR | IC50 | > | 100000.0 | nM | - |
| CHEMBL500883 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL511046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL472603 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL499820 | N4-hydroxycytosine | IC50 | > | 100000.0 | nM | - |
| CHEMBL472604 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL470521 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210951 | — | IC50 | > | 100000.0 | nM | - |