Assay Detail
Functional
CHEMBL977105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human MCF7 cells after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.68 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451477 | — | — | 1 | 4.82 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.82 |
| CHEMBL472604 | — | — | 1 | 4.57 |
| CHEMBL503357 | — | — | 1 | 4.50 |
| CHEMBL503034 | — | — | 1 | - |
| CHEMBL475578 | — | — | 1 | - |
| CHEMBL473232 | — | — | 1 | - |
| CHEMBL475258 | — | — | 1 | - |
| CHEMBL38107 | — | — | 1 | - |
| CHEMBL465176 | HYDRACYCLUR | — | 1 | - |
| CHEMBL36394 | — | — | 1 | - |
| CHEMBL37731 | IODACYCLUR | — | 1 | - |
| CHEMBL208654 | IODMETACYCLUR | — | 1 | - |
| CHEMBL500883 | — | — | 1 | - |
| CHEMBL511046 | — | — | 1 | - |
| CHEMBL472603 | — | — | 1 | - |
| CHEMBL499820 | N4-hydroxycytosine | — | 1 | - |
| CHEMBL470521 | — | — | 1 | - |
| CHEMBL210951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451477 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL472604 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL503357 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL503034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475578 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL473232 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL475258 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL38107 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL465176 | HYDRACYCLUR | IC50 | > | 100000.0 | nM | - |
| CHEMBL36394 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL37731 | IODACYCLUR | IC50 | > | 100000.0 | nM | - |
| CHEMBL208654 | IODMETACYCLUR | IC50 | > | 100000.0 | nM | - |
| CHEMBL500883 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL511046 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL472603 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL499820 | N4-hydroxycytosine | IC50 | > | 100000.0 | nM | - |
| CHEMBL470521 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL210951 | — | IC50 | > | 100000.0 | nM | - |