Assay Detail
Binding
CHEMBL977364
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of voltage-dependent N-type calcium channel in human IMR32 cells assessed as effect on calcium influx
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.68 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL453084 | — | — | 1 | 6.09 |
| CHEMBL382072 | — | — | 1 | 6.00 |
| CHEMBL453088 | — | — | 1 | 5.85 |
| CHEMBL452076 | CILNIDIPINE | 3.0 | 1 | 5.80 |
| CHEMBL453604 | — | — | 1 | 5.77 |
| CHEMBL370409 | — | — | 1 | 5.77 |
| CHEMBL453605 | — | — | 1 | 5.75 |
| CHEMBL511062 | — | — | 1 | 5.75 |
| CHEMBL452072 | — | — | 1 | 5.70 |
| CHEMBL451817 | — | — | 1 | 5.68 |
| CHEMBL508180 | — | — | 1 | 5.60 |
| CHEMBL452073 | — | — | 1 | 5.52 |
| CHEMBL451812 | — | — | 1 | 5.52 |
| CHEMBL508181 | — | — | 1 | 5.46 |
| CHEMBL451813 | — | — | 1 | 5.41 |
| CHEMBL451811 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL453084 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL382072 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL453088 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL452076 | CILNIDIPINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL453604 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL370409 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL453605 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL511062 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL452072 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL451817 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL508180 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL452073 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL451812 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL508181 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL451813 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL451811 | — | IC50 | = | 5800.0 | nM | 5.24 |