Assay Detail
Binding
CHEMBL977795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]SDF1alpha from CXCR4 expressed in CHOK1 cells
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 9.09 | 9.09 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | 4.0 | 2 | 9.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL18442 | PLERIXAFOR | Inhibition | = | 100.0 | % | - |