Assay Detail
Binding
CHEMBL977797
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Displacement of [125I]SDF1alpha from CCR2/CXCR4 expressed in CHOK1 cells
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 10.25 | 10.40 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | 4.0 | 2 | 10.40 |
| CHEMBL41275 | — | — | 2 | 10.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18442 | PLERIXAFOR | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL41275 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL18442 | PLERIXAFOR | Inhibition | = | 87.1 | % | - |
| CHEMBL41275 | — | Inhibition | = | 38.1 | % | - |